Programação ISZB

8:00 – 8:30	Registration ISZB Registration
	Room 5
8:30 – 9:00	Welcome ISZB Welcome
9:00 – 10:00	Plenary 1 Chair: Samantha Pitt Michal Hershfinkel Zn2+ Acts as a First Messenger via the Zinc Sensing Receptor
10:00 – 10:30	Coffee Break
10:30 – 12:00	Zinc Signaling in Cancer Chairs: Ling Huang; Fanis Missirlis 10:30–10:55 — Ling Huang Determine the role of zinc transporter SLC39A10 in pancreatic cancer 10:55–11:20 — Oleh Khalimonchuk Mitochondrial zinc metallopeptidase OMA1 as a new therapeutic target in treatment-refractory breast cancer 11:20–11:45 — Zakeya Baalawy An investigation to determine the role of zinc and ZIP family metal transporters in Renal Cell Carcinoma 11:45–12:00 — Panel Discussion
12:00 – 13:30	Lunch on your own
13:30 – 15:00	Zinc in Immunity Chairs: Daren Knoell; Divya Ramnath 13:30–13:55 — Daren Knoell Zinc Dyshomeostasis Alters the Gut Microbiome Causing Metabolic Disruption of Macrophage-Mediated Bacterial Clearance in the Lung 13:55–14:20 — Stefan Feske Different ZIP transporters control CD4 T cell function in autoimmunity and immunity to infection 14:20–14:45 — Matthew Sweet Understanding and manipulating the antibacterial zinc toxicity response in macrophages for anti-infective design 14:45–15:00 — Panel Discussion
15:00 – 15:30	Coffee Break
15:30 – 16:30	Zinc in Neurobiology Chairs: Satoshi Takenaka, Michal Hershfinkel 15:30–15:55 — Richard Dyck Vesicular zinc modulates postnatal hippocampal neurogenesis and experience-dependent plasticity 15:55–16:20 — Charles Anderson The roles of the zinc transporter proteins ZnT3 and ZIP12 in synaptic function and synaptic structure in the mouse auditory cortex. 16:20–16:30 — Panel Discussion
16:30 – 17:30	Zinc Imaging and Biosensors Chair: Christer Hogstrand 16:30–16:55 — Carlos Tejeda-Guzmán Zinc chelation induces visible pigment granules and loss of autofluorescence in Drosophila Malpighian tubules 16:55–17:20 — Wen-hong Li A versatile fluorescent zinc indicator, ZIGIR-2, for imaging zinc rich vesicles in living cells 17:20–17:30 — Panel Discussion
18:00 – 19:30	Opening Ceremony Opening Ceremony
20:00 – 22:00	Cocktail Opening Cocktail Reception

	Room 5
8:30 – 9:30	Trainee Session 1 Chairs: Georgia Farr; Yahav Ishay 08:30–08:45 — Emma Dalton 'Ramping' up macrophage antibacterial zinc toxicity to combat antibiotic-resistant bacterial infections 08:45–09:00 — Sergio Pereira Lima Neto Impacts of excess zinc on the Chromobacterium violaceum transcriptome revealed by RNAseq analysis 09:00–09:15 — Braden Rue A high-affinity sensor mitoGZnP4s uncovers a TRPML1-MCU axis governing mitochondrial Zn2+ uptake 09:15–09:30 — Xiujuan Tong Real-time Visualization and Quantification of Zinc Dynamics in Live Zebrafish using a Novel FRET-based Probe
9:30 – 10:00	Coffee Break
10:00 – 11:30	Zinc Transporters Chairs: Toshiyuki Fukada; Zakeya Baalawy 10:00–10:25 — Yuta Amagai Roles of Zinc Transporters in Maintaining ER and Golgi Zinc Homeostasis 10:25–10:50 — Zhi Luo Recent progress in the regulation of zinc metabolism and homeostasis in the vertebrates 10:50–11:15 — Fudi Wang Transporters and Zincology: Decoding Zinc Homeostasis in Health and Disease 11:15–11:30 — Panel Discussion
11:30 – 13:30	Lunch Complementary: Montecarmo Restaurant
14:00 – 19:30	Cultural Tour Cultural Tour (buses depart at 2:00 pm)
19:30 – 22:00	Congress Dinner Congress Dinner

	Room 5
08:30 – 09:30	Plenary 3 Chair: Lothar Rink Toshiyuki Fukada From Cytokine to Zinc Biology: New Insights into Zinc Transporters' Function, Disease, and Drug Development
09:30 – 10:00	Coffee Break
10:00 – 11:30	Zinc in Development and Reproduction Chairs: Wen-hong Li; Stefan Feske 10:00–10:25 — Christer Hogstrand The membrane androgen receptor, ZIP9, regulates the hypothalamic-pituitary-gonadal (HPG) axis and is essential for female fertility in zebrafish 10:25–10:50 — Fanis Missirlis Physiological relevance of prominent zinc storage granules in the Malpighian Tubules of Drosophila melanogaster larvae. 10:50–11:15 — Satoshi Takenaka Pathophysiological Significance of Impaired KAT7-Dependent Histone H3K14 Acetylation During Zinc Deficiency 11:15–11:30 — Panel Discussion
11:30 – 12:30	Business Meeting Chair: Richard Dyck ISZB Business Meeting
12:30 – 13:30	Lunch on your own
13:30 – 15:30	Zinc in Human Health, Disease, and Aging Chairs: Sunita Ho; Sangyong Choi 13:30–13:55 — Christopher Elitt Gene transcripts in plasma exosomes for specific zinc transporters and metallothioneins are downregulated in human preterm infants 13:55–14:20 — Samantha Pitt Altered Zn2+ homeostasis in Niemann-Pick C1 disease results in impaired NAADP-mediated lysosomal Ca2+- dynamics 14:20–14:45 — Sangyong Choi A Common Genetic Variant Near the PPCDC Gene Regulates the Cellular Zinc Homeostasis. 14:45–15:10 — Sunita Ho Zinc signatures inform site-specific pathways of kidney stone formation 15:10–15:30 — Panel Discussion
15:30 – 15:45	Bio/Coffee Break (on your own)
15:45 – 17:00	Trainee Session 2 Chairs: Emma Dalton; Braden Rue 15:45–16:00 — Oscar Antonio Nunez-Gaytan The possible involvement of serotonin in regulating zinc homeostasis 16:00–16:15 — Yahav Ishay Early to mature, late to connect: ZnR/GPR39 in neuronal development 16:15–16:30 — Georgia Farr Novel roles for ZIP7 in metastasis-associated behaviours of breast cancer 16:30–16:45 — Raul Jorge-Marrero Effect of subcutaneous kynurenine injection on systemic zinc regulation in murine models 16:45–17:00 — Weronika Leszczyńska Characteristics of interaction of zinc and copper ions with human metallothioneins (MT1a-MT4)
17:00 – 17:30	Coffee Break (coffee and food available)
17:30 – 19:00	Poster Session 101. Martyna Uściła Biophysical and Biochemical Characterization of Human Metallothionein MT1HL1 102. Zuzanna Janiec Zn(II)-induced homodimerization of C-terminal cysteine cluster of MTF-1 transcription factor 103. Kevin Shu-Leung Lai Zinc Deficiency at ICU Admission: Longitudinal Trends and Diagnostic Stratification 104. Sang Won Suh Transcranial Focused Ultrasound Enhances Adult Hippocampal Neurogenesis via Vesicular Zinc Signaling 105. Kaitlin Bainer Investigating the roles of synaptic zinc in inhibitory neurotransmission in the mouse auditory cortex 106. Yahav Ishay Loss of ZnR/GPR39 accelerates neuronal maturation but impairs network integration 107. Oscar Antoni Nunez-Gaytan The possible involvement of serotonin in regulating zinc homeostasis 108. Rayli Ruby Synaptic zinc contributes to AMPA receptor maturation in the mouse auditory cortex 109. Emma Trate The discovery and refinement of small-molecule compounds that can act as ZIP12 agonists and antagonists 110. Raul Jorge-Marrero Effect of subcutaneous kynurenine injection on systemic zinc regulation in murine models 111. Cynthia Sarai Sanchez-Gonzalez How does Rab32 function in the biogenesis of zinc storage granules? 112. Braden Rue A high-affinity sensor mitoGZnP4s uncovers a TRPML1-MCU axis governing mitochondrial Zn2+ uptake 113. Sergio Pereira Lima Neto Impacts of excess zinc on the Chromobacterium violaceum transcriptome revealed by RNA-seq analysis 114. Xuijuan Tong Real-time visualization and quantification of zinc dynamics in live zebrafish using a novel FRET-based probe 115. Emma Dalton 'Ramping' up macrophage antibacterial zinc toxicity to combat antibiotic-resistant bacterial infections 116. Wojciech Bal Silver ions destroy zinc fingers, but glutathione comes to the rescue
20:00 – 22:00	Social Meeting Social Meeting (Sao Paolo bar with live music)

	Room 5
9:00 – 10:00	Plenary 4 · Frederickson Prize Chair: Richard Dyck Lothar Rink Zinc in Immunosenescence and Malnutrition
10:00 – 10:30	Coffee Break
10:30 – 12:00	Zinc in Host / Pathogen Dynamics Chairs: Derrick Samuelson; Eusondia Arnett 10:30–10:55 — Derrick Samuelson Microbiota-derived metallophores contribute to IBD severity 10:55–11:20 — Divya Ramnath Harnessing Zinc Toxicity Pathways to Overcome Antimicrobial Resistance 11:20–11:45 — Eusondia Arnett Mycobacterium tuberculosis subverts macrophage-mediated defence through exploitation of the Zn transporter ZIP8 11:45–12:00 — Panel Discussion
12:00 – 12:30	Award Presentations Award Presentations
12:30 – 13:30	Closing Ceremony Closing Ceremony