Programação da ISTERH – CBTOX 2026

Programação da ISTERH

9:00 - 10:30am	ISTERH Symposium 1: Selenium Metabolism: From Molecular Pathways to Personalized Health Chair: Barbara Cardoso, Co-Chair: Lucia Seale 9:00–9:02am — Introduction 9:02–9:24am — Selenoprotein gene expression is downregulated in plasma exosomes from human preterm infantsChristopher M Elitt 9:24–9:46am — Diverse roles of selenoproteins in B cell development, homeostasis, and humoral immunityGirish S. Kirimanjeswara 9:46–10:08am — Loss of selenocysteine lyase disrupts mitochondria function in brown adipose tissueBriana Shimada 10:08–10:30am — Exposure to high doses of selenium in the Amazon riverside population: Use of omics tools to evaluate mechanisms associated with toxicityLígia Moriguchi Watanabe
10:30 - 11:00am	Coffee Break with Snacks
11:00 - 12:00pm	ISTERH Symposium 2: The Fluoride Paradox: Health Protector or Hidden Risk? Chair: Sofia Pessanha, Co-Chair: Ana Carolina Alves de Oliveria 11:00–11:20am — Rationale use of fluoride: Guidelines across different countriesMarília Buzalaf 11:20–11:40am — Fluoride uptake in mineralized tissues: What advanced spectroscopies revealSofia Pessanha 11:40am–12:00pm — Prenatal and early-life fluoride exposureAna Carolina Alves
12:00 - 1:00pm	Lunch
1:00 - 2:30pm	ISTERH Symposium 3: Metals Matter: Bridging Advanced Technologies and Neuro-Effects Part I Chair: Xuemei Huang 1:02–1:24pm — X-ray fluorescence in the assessment of environmental exposures and their relationship to mental health outcomesDavid Fleming 1:24–1:46pm — Soft tissue-mimicking phantoms for in vivo bone lead detection with a portable x-ray fluorescence spectrometerAna Pejovic-Milic 1:46–2:08pm — Portable x-ray fluorescence to measure manganese and mercury in toenail in vivoXinxin Zhang 2:08–2:30pm — Metal distribution and association patterns in postmortem neurodegenerative brains using synchrotron micro-x-ray fluorescenceLinda Nie
2:30 - 4:00pm	ISTERH Symposium 4: Metals Matter: Bridging Advanced Technologies and Neuro-Effects Part 2 Chair: Linda Nie 2:30–2:32pm — Introduction 2:32–2:54pm — Early-life lead exposure and late-life cognitive effectsMarc Weisskopf 2:54–3:16pm — Industrial colors, global consequences: Cr(VI) neurotoxicity in focusJohnny Wise 3:16–3:38pm — Multimodal mass spectrometry imaging to elucidate the mechanisms of ferroptosis in epithelial ovarian cancerBrittney L. Gorman 3:38–4:00pm — MicroRNA expression as a potential early biomarker of lead (Pb) exposure: epigenetic insights from weldersXuemei Huang
4:00 - 4:30pm	Coffee Break with Snacks
4:30 - 5:30pm	ISTERH Symposium 5: Metabolic and Epigenetic Mechanisms of Arsenic-Associated 3D chromatin reorganization, DNA Damage Response and Carcinogenesis Chair: Fei Chen 4:30–4:32pm — Introduction 4:32–4:54pm — Molecular underpinnings in the establishment of an oncogenic 3D genome in response to environmental arsenic exposureYvonne Fondufe-Mittendorf 4:54–5:16pm — Arsenic exposure reshapes 3D chromatin architecture to activate KLF4 through Nrf2Fei Chen 5:16–5:38pm — Deciphering mutational processes and pathways reshaped by arsenic in UV-induced skin carcinogenesisKe Jian Liu 5:38–6:00pm — Biomarkers of aging, carcinogenesis, and environmental epigeneticsBernardo Lemos
6:00 - 8:00pm	Opening Ceremony
8:00 - 10:00pm	Opening Cocktail Reception (L'atelier Space – WTC)

8:00 - 8:30am	ISTERH Registration
8:30 - 9:30am	Plenary - "Everything, Everywhere, all at Once: How the Exposome is Shaping the Future of Health" Dr. Roel Vermeulen (Utrecht University, Netherlands)
9:30 - 10:00am	Coffee Break with Snacks
10:00 - 11:40am	ISTERH Symposium 6: Toxic Metals and Other Environmental Chemical Exposures in Human Diseases Chair: Yinsheng Wang, Co-Chair: Donna Zhang 10:00–10:20am — NRF2 preserves lung barrier integrity and mitigates arsenic-induced pulmonary inflammationDonna Zhang 10:20–10:40am — The eNAMPT–TLR4 danger signal in arsenic-primed lung fibrosisJoe GN Garcia 10:40–11:00am — Microplastics, plastic-associated EDCs, and cardiovascular diseaseChangcheng Zhou 11:00–11:20am — Complete decoding of tsRNA modifications reveals structural and functional principlesQi Chen 11:20–11:40am — Environmental exposure, epitranscriptomic alterations, and neurological diseasesYinsheng Wang
11:40am - 1:10pm	ISTERH Symposium 7: Metals and Inflammation Chair: Hellen Weinschutz Mendes, Co-Chair: Nishant Sharma 11:40–11:42am — Introduction 11:42am–12:04pm — Immune-mediated responses to inhaled tungsten particles and cardiac injuryAlicia Bolt 12:04–12:26pm — Lead(Pb)-induced neuroinflammation in the developing zebrafish brainHellen Weinschutz Mendes 12:26–12:48pm — Peripheral HIF-2 deficiency attenuates manganese-induced motor deficits independent of brain Mn loadNishant Sharma 12:48–1:10pm — Blood magnesium level and its metabolomic signatures are associated with lower risk of liver cancer compared to both no liver disease and liver disease controlsXuehong Zhang
1:10 - 2:00pm	Break (prepare for afternoon departure 1:10pm - 2:00pm)
2:00 - 8:30pm	Cultural Tour (Buses depart at 2pm. Boxed lunches on bus.)
8:30 - 10:00pm	Congress Dinner

8:30 - 9:30am	ISTERH Symposium 8: Manganese and Iron - Mechanisms and Interaction in Neurological Disorders Chair: Ulrike Dydak 8:30–8:50am — Manganese and iron transporters, BTBD9, and alpha-synuclein interactions in Restless LegMichael Aschner 8:50–9:10am — Metal constituents in air pollution and sex-dependent neurodegenerative riskMarissa Sobolewski 9:10–9:30am — Neuroimaging of manganese toxicity in welders with a focus on ironUlrike Dydak
9:30 - 10:00am	Coffee Break with Snacks
10:00am - 12:00pm	ISTERH Symposium 9: Metal Matter: Tracing the Path from Exposure to Carcinogenesis Chair: Xiang Xue, Co-Chair: Ke Jian Liu 10:00–10:20am — Maternal exposure to cadmium increases offspring risk for hepatocellular carcinomaLu Cai 10:20–10:40am — Arsenic exposure and liver diseaseHui-Chen Wu 10:40–11:00am — Uranium-laden particulate dust alters intestinal epithelial proliferation and differentiationJulie G In 11:00–11:20am — PINK1 deficiency facilitates mitochondrial iron accumulation and colon tumorigenesisXiang Xue 11:20–11:40am — Lysosomes as executors of cellular life-and-death decisions in cadmium carcinogenesisWing-Kee Lee 11:40am–12:00pm — Nickel-induced m6A dysregulation promotes malignant cell transformationHong Sun
12:00 - 1:30pm	Lunch & Poster Session ISTERH Poster Abstracts — Friday, June 5, 2026 ISTERH Poster 1 Metal/Metalloid accumulation and gene synergism accelerate AD pathobiology Leandro C Freitas-Lima^1*; Kevin P Kotredes²; Juliet A Moncaster^3,4; Scott Persohn¹; Kierra Eldridge¹; Zeynep Sarica²; Olga Minaeva^3,4; Nicola Lupoli³; Gareth R Howell²; Lee E Goldstein^3,4; Paul R Territo^1,5# ¹Indiana University School of Medicine, Indianapolis, IN, USA; ²The Jackson Laboratory, Bar Harbor, ME, USA; ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; ⁴Boston University Alzheimer's Disease Research Center, Boston, MA, USA; ⁵Stark Neuroscience Research Institute; ^#pterrito@iu.edu
1:30 - 3:30pm	ISTERH Symposium 10: Trace Metals and Environmental Neurotoxicants in Neurodegeneration: Clinical and Mechanistic Insights Chair: Giselle Cerchiaro, Co-Chair: Yansheng Du 1:30–1:50pm — Copper imbalance and zinc intervention in neurodegeneration and mental disorders: Clinical and translational perspectivesRosanna Squitti 1:50–2:10pm — Impact of chronic copper exposure on the gut microbiota and accelerated development of Alzheimer's disease phenotypes in miceMasashi Kitazawa 2:10–2:30pm — Co-exposure to environmental lead and hypertension exacerbates astrocyte senescence via mtDNA-mediated cGAS phase separationYanshu Zhang 2:30–2:50pm — Persistent vulnerabilities in neurons following lead (Pb) exposure and implications for Alzheimer's DiseaseChongli Yuan 2:50–3:10pm — Endothelial PAI-1 drives lead-induced cerebral amyloid angiopathy via activation of C3⁺ Decorin⁺ A1-like astrocytesYansheng Du 3:10–3:30pm — A novel copper chelator reverses neuropathology and improves cognition in an Alzheimer's Disease modelGiselle Cerchiaro
3:30 - 5:00pm	ISTERH Symposium 11: Glutamatergic, GABAergic, Dopaminergic, and Apoptotic Pathways in Metals Neurotoxicity Chair: Wagner Tamagno 3:30–3:32pm — Introduction 3:32–3:54pm — Disruption of glutamatergic neurotransmission by developmental lead exposure drives cognitive impairments in zebrafish larvaeWagner Tamagno 3:54–4:16pm — Hexavalent chromium preferentially targets GABAergic neurons in a Caenorhabditis elegans model: Assessing neuronal morphologies and altered behaviorsSamuel Vielee 4:16–4:38pm — In-vivo repressor screen identifies dopaminergic and glutamatergic neurons as targets of manganese toxicityAshvini Melkote 4:38–5:00pm — Air-pollution derived Fe-oxide nanoparticle inhalation and neurodegenerative riskJithin V. George
5:00 - 5:30pm	Coffee Break with Snacks
5:30 - 7:10pm	ISTERH Symposium 12: Metal Exposure and Health Effects: Communities at Risk Chair: Ellen Wells, Co-Chair: Tomasso Filippini 5:30–5:50pm — Longitudinal association metal exposure and mild cognitive impairment in ItaliansTommaso Filippini 5:50–6:10pm — Health effects of high selenium exposure through drinking water in ItalyMarco Vinceti 6:10–6:30pm — Metal exposure in northwestern Indiana, USAEllen Wells 6:30–6:50pm — Multi-metal concentrations in bone among residents of Fallujah, IraqAaron Specht 6:50–7:10pm — Lead exposure and health risks in riparian communities of the Amazon: linking diet, environment, and vulnerabilityFernando Barbosa, Jr.
7:10 - 8:00pm	ISTERH Business Meeting
8:00 - 10:00pm	Social Meeting

8:00 - 8:30am	ISTERH Registration
8:30 - 9:30am	Track 1 Plenary - Immunotoxicity of Cannabinoids
8:30 - 10:00am	Track 2 (Parallel) ISTERH Symposium 13: Epidemiology, Mechanisms, and Genetics of Manganese Homeostasis and Neurotoxicity Chair: Somshuvra Mukhopadhyay 8:30–8:32am — Introduction 8:32–8:54am — Role of SLC30A10 in modulating Mn homeostasis and neurotoxicitySomshuvra Mukhopadhyay 8:54–9:16am — Congruence of human and animal model findings shows that developmental manganese exposure causes lasting neurodevelopmental deficits accompanied with pre-frontal cortex dysfunctionDonald R. Smith 9:16–9:38am — Polyglutamine aggregation in the Caenorhabditis elegans model of Huntington's disease alters manganese homeostasisDaiana Silva de Ávila 9:38–10:00am — Developmental pathophysiology of childhood-onset manganese-induced dystonia-Parkinsonism in Slc39a14-KO miceTomás R. Guilarte
10:00 - 10:30am	Coffee Break with Snacks
10:30 - 12:30pm	ISTERH Symposium 14: Brain Barriers in the Etiology of Brain Diseases and Chemical-induced Neurotoxicities Chair: Wei Zheng, Co-Chair: Jessica Plavicki 10:30–10:50am — Introduction to blood-brain interfaces and the impact of developmental insults on brain barrier functionsJean-Francois Ghersi-Egea 10:50–11:10am — sox9a and sox9b as critical regulators of dioxin-induced neurovascular toxicityJess Plavicki 11:10–11:30am — Detrimental effects of hypoxemia on the brain barriers: A possible role in fine particulate matter-induced damage to the brainZoran Redzic 11:30–11:50am — Lead and selenium in amyotrophic lateral sclerosis (ALS): Evidence from human cerebrospinal fluid studiesPer M Roos 11:50am–12:10pm — Choroid plexus mitochondrial dysfunction as a driver of suppressed CSF production and clearance failure with trace-metal imbalance in neurodegenerationPer Selnes 12:10–12:30pm — Novel concept of choroid Epithelia-Ventricle Interactive Lineage (EVIL) axis in Brain: Implication in metal-induce neurotoxicitiesWei Zheng
12:30 - 1:30pm	Closing Session

Poster session